2. Investigation of microtubule interactions with kinetochore and microtubule associated proteins
We study how microtubule behavior is regulated in cells by associated proteins, and how proteins couple microtubule dynamics to chromosome motions. Some of our favorite questions include:
1) How does the key kinetochore complexes, NDC80 and Dam1 (in yeast) function at the molecular level?
2) How do the most faithful partners of tubulin, the end-binding (EB) proteins, recognize growing microtubule tips and modulate microtubule dynamics?
3) How do other microtubule regulators, such as TOG-contaning polymerases, kinesin and stathmin depolymerases and severing enzymes catalyze changes in microtubule behavior?